Rekombinanter DKK3 Antikörper

Produktnummer ABIN8093133

Der Kaninchen Monoklonal anti-DKK3 Antikörper (Klon 21D17) (ABIN8093133) detektiert spezifisch DKK3 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter DKK3 Antikörper (ABIN8093133)

Target: DKK3

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser DKK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 21D17

Produktdetails anti-DKK3 Antikörper

Verwendungszweck: DKK3 Antibody / Dickkopf-related protein 3

Aufreinigung: Purified

Immunogen: A synthesized peptide derived from human Dickkopf-related protein 3 was used as the immunogen for the DKK3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DKK3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DKK3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu DKK3

Target: DKK3

Hintergrund: DKK3 antibody targets Dickkopf-related protein 3, encoded by the DKK3 gene. DKK3 is a secreted glycoprotein belonging to the Dickkopf family, a group of proteins originally identified as modulators of Wnt signaling. Unlike other Dickkopf family members, DKK3 does not function as a classical Wnt antagonist and instead exhibits context-dependent regulatory roles in cell signaling, differentiation, and tissue homeostasis. DKK3 is synthesized intracellularly and secreted into the extracellular space, where it can influence cell-cell communication.

Functionally, Dickkopf-related protein 3 has been implicated in regulation of cell proliferation, apoptosis, and differentiation. DKK3 activity appears to depend on cellular context and tissue type, with reported involvement in modulation of growth factor signaling pathways and stress-responsive cellular programs. Through these mechanisms, DKK3 contributes to maintenance of normal tissue architecture and regulation of cellular responses to environmental cues. A DKK3 antibody supports studies focused on extracellular signaling and regulatory protein function.

DKK3 expression is detected in a variety of tissues, including epithelial and stromal compartments. It is often associated with differentiated cell states and has been reported to localize both intracellularly during synthesis and extracellularly following secretion. Changes in DKK3 expression levels have been linked to alterations in cellular differentiation status and signaling balance.

From a disease-relevance perspective, DKK3 has been widely studied in cancer biology. Reduced or altered DKK3 expression has been reported in multiple tumor types and is frequently associated with tumor progression, invasion, and poor prognosis. DKK3 has therefore been proposed as a tumor suppressor-associated protein and a potential biomarker for disease state and therapeutic response. These associations make DKK3 an important target for research into cancer-related signaling pathways.

At the molecular level, Dickkopf-related protein 3 contains conserved cysteine-rich domains characteristic of the Dickkopf family, which support protein folding and extracellular interactions. Post-translational modifications and secretion dynamics can influence its apparent behavior in biochemical assays. DKK3 antibody reagents support research applications focused on cell signaling, tumor biology, and extracellular regulatory mechanisms, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9UBP4