PAPPA Antikörper

Produktnummer ABIN8065521

Der Maus Monoklonal anti-PAPPA Antikörper wird verwendet zum Nachweis von PAPPA in Proben von Human. Er wurde validiert für IHC, WB und ELISA.

Kurzübersicht für PAPPA Antikörper (ABIN8065521)

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAPPA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Güteklasse: Carrier-free

Klon: PAPP A 1-24

Produktdetails anti-PAPPA Antikörper

Verwendungszweck: Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody

Spezifität: ABIN8065521 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. The epitope of ABIN8065521 is different from ABIN8065522 and ABIN8065520. The epitope is located on the PAPP-A subunit of the heterotetramer.

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Purified human PAPP-A

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Andere Bezeichnung: Pregnancy Associated Plasma Protein A

Hintergrund: PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnancy-associated plasma protein A, pappalysin 1,Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.,PAPPA,Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).

Molekulargewicht: 500 kDa (tetramer), 180 kDa (monomer)

Gen-ID: 5069

UniProt: Q13219