PAPPA Antikörper (AA 351-523)

Produktnummer ABIN6940248

Produktdetails anti-PAPPA Antikörper

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Bindungsspezifität: AA 351-523

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAPPA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Spezifität: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)

Klon: PAPPA-2715

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Placenta.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Andere Bezeichnung: PAPPA (PAPPA Produkte)

Synonyme: 8430414N03Rik antikoerper, IGFBP-4ase antikoerper, PAG1 antikoerper, PAPP-A antikoerper, ASBABP2 antikoerper, DIPLA1 antikoerper, PAPA antikoerper, PAPPA1 antikoerper, Pappa antikoerper, pappalysin 1 antikoerper, pregnancy-associated plasma protein A antikoerper, PAPPA antikoerper, Pappa antikoerper, Pappa1 antikoerper

Molekulargewicht: 181kDa

Gen-ID: 5069

UniProt: Q13219