Ghrelin Antikörper

Produktnummer ABIN8065477

Der Maus Monoklonal anti-Ghrelin Antikörper (Klon 121) (ABIN8065477) detektiert spezifisch Ghrelin in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Ghrelin Antikörper (ABIN8065477)

Target: Ghrelin (GHRL)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Ghrelin Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Carrier-free

Klon: 121

Produktdetails anti-Ghrelin Antikörper

Verwendungszweck: Anti-Ghrelin Antibody

Spezifität: ABS 052-121 binds human ghrelin.

Homologie: Canine,Feline,Human,Mouse,and Rat

Aufreinigung: Protein A or Protein G purified

Immunogen: Synthetic ghrelin (14-28)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 12 months

Details zu Ghrelin

Target: Ghrelin (GHRL)

Andere Bezeichnung: Ghrelin

Hintergrund: GHRL, MTLRP, appetite-regulating hormone, In2c-preproghrelin, ghrelin, growth hormone secretagogue receptor ligand, ghrelin/obestatin preprohormone, ghrelin/obestatin prepropeptide, growth hormone-releasing peptide, motilin-related peptide, prepro-appetite regulatory hormone, preproghrelin,Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28. {ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}., [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:35027551}., [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}., [Obestatin]: May be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.,GHRL,Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing, Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3, this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food reflect those of active ghrelin.

Molekulargewicht: 13 kDa (pro-ghrelin), 6 kDa (mature ghrelin)

Gen-ID: 51738

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour