Gelsolin Antikörper

Produktnummer ABIN8065474

Der Maus Monoklonal anti-Gelsolin Antikörper (Klon 2E1) (ABIN8065474) detektiert spezifisch Gelsolin in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Gelsolin Antikörper (ABIN8065474)

Target: Gelsolin (GSN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Gelsolin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Güteklasse: Carrier-free

Klon: 2E1

Produktdetails anti-Gelsolin Antikörper

Verwendungszweck: Anti-Gelsolin Antibody

Spezifität: ABS 017-20 binds human gelsolin.

Homologie: Human

Aufreinigung: Protein A or Protein G purified

Immunogen: Gelsolin purified from human plasma

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C without exposure to light

Haltbarkeit: 24 months

Details zu Gelsolin

Target: Gelsolin (GSN)

Andere Bezeichnung: Gelsolin

Hintergrund: GSN, ADF, AGEL, AMYLD4, gelsolin, actin-depolymerizing factor, brevin, epididymis secretory sperm binding protein,Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:19666512, ECO:0000269|PubMed:20393563}.,GSN,Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions.

Molekulargewicht: 83 kDa

Gen-ID: 2934

UniProt: P06396

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie