XIAP Antikörper (AA 15-244) (Fluoro488)

Produktnummer ABIN8054593

Der Fluoro488-konjugierte Maus Monoklonal anti-XIAP Antikörper (Klon 3G2G1) (ABIN8054593) detektiert spezifisch XIAP in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für XIAP Antikörper (AA 15-244) (Fluoro488) (ABIN8054593)

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XIAP Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Klon: 3G2G1

Produktdetails anti-XIAP Antikörper (Fluoro488)

Bindungsspezifität: AA 15-244

Verwendungszweck: Anti-XIAP Antibody (monoclonal, 3G2G1) Fluoro488 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human XIAP shares 89.4%,90.7% amino acid (aa) sequence identity with mouse,rat XIAP,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human XIAP recombinant protein (Position: A15-V244). Human XIAP shares 89.4% and 90.7% amino acid (aa) sequence identity with mouse and rat XIAP, respectively.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Andere Bezeichnung: XIAP

Hintergrund:

Background: XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.

Gene Full Name: X-linked inhibitor of apoptosis

Gen-ID: 331

UniProt: P98170

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Transition Metal Ion Homeostasis