RECQL2 Antikörper (AA 122-240) (Fluoro647)

Produktnummer ABIN8054181

Der Kaninchen Polyklonal anti-RECQL2 Antikörper wird verwendet zum Nachweis von RECQL2 in Proben von Human und Ratte. Er wurde validiert für FACS.

Kurzübersicht für RECQL2 Antikörper (AA 122-240) (Fluoro647) (ABIN8054181)

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RECQL2 Antikörper ist konjugiert mit Fluoro647

Applikation: Flow Cytometry (FACS)

Produktdetails anti-RECQL2 Antikörper (Fluoro647)

Bindungsspezifität: AA 122-240

Verwendungszweck: Anti-Werner's syndrome helicase WRN/WRN Antibody Fluoro647 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human WRN recombinant protein (Position: Q122-N240). Human WRN shares 84% amino acid (aa) sequence identity with mouse WRN.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human WRN recombinant protein (Position: Q122-N240). Human WRN shares 84% amino acid (aa) sequence identity with mouse WRN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Andere Bezeichnung: WRN

Hintergrund:

Background: Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Gene Full Name: WRN RecQ like helicase

Gen-ID: 7486

UniProt: Q14191

Pathways: DNA Reparatur