UBD Antikörper (N-Term) (APC)

Produktnummer ABIN8052037

Der APC-konjugierte Kaninchen Polyklonal anti-UBD Antikörper (ABIN8052037) detektiert spezifisch UBD in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für UBD Antikörper (N-Term) (APC) (ABIN8052037)

Target: UBD (Ubiquitin D (UBD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBD Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-UBD Antikörper (APC)

Bindungsspezifität: N-Term

Verwendungszweck: Anti-Diubiquitin/UBD Antibody APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse,rat sequences by five amino acids.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Diubiquitin, different from the related mouse and rat sequences by five amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu UBD

Target: UBD (Ubiquitin D (UBD))

Andere Bezeichnung: UBD

Hintergrund:

Background: Ubiquitin D, also called UBD or FAT10 is a protein that in humans is encoded by the UBD gene. This gene is mapped to 6p22.1. Ubiquitin-like protein modifier can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome in a NUB1L-dependent manner. This gene may be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. It may be involved in the formation of aggresomes when proteasome is saturated or impaired. This gene mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). It probably functions as a survival factor.

Gene Full Name: ubiquitin like modifier D

Sequence Similarities: Contains 2 ubiquitin-like domains.

Gen-ID: 10537

UniProt: O15205

Pathways: Ubiquitin Proteasome Pathway