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UBD Antikörper (Internal Region)

UBD Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265840
  • Target Alle UBD Antikörper anzeigen
    UBD (Ubiquitin D (UBD))
    Bindungsspezifität
    • 10
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 43
    • 43
    • 19
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 56
    • 4
    Kaninchen
    Klonalität
    • 48
    • 12
    Polyklonal
    Konjugat
    • 25
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UBD Antikörper ist unkonjugiert
    Applikation
    • 48
    • 24
    • 23
    • 21
    • 8
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    UBD Antibody detects endogenous levels of total UBD.
    Homologie
    Pig,Bovine,Horse,Rabbit
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human UBD, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product UBD Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    UBD (Ubiquitin D (UBD))
    Andere Bezeichnung
    UBD (UBD Produkte)
    Synonyme
    FAT10 antikoerper, GABBR1 antikoerper, UBD-3 antikoerper, ubiquitin D antikoerper, UBD antikoerper, Ubd antikoerper
    Hintergrund

    Description: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).

    Gene: UBD

    Molekulargewicht
    18kDa
    Gen-ID
    10537
    UniProt
    O15205
    Pathways
    Ubiquitin Proteasome Pathway
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