TDP1 Antikörper (AA 1-499) (Fluoro594)

Produktnummer ABIN8051868

Der Kaninchen Polyklonal anti-TDP1 Antikörper wird verwendet zum Nachweis von TDP1 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für TDP1 Antikörper (AA 1-499) (Fluoro594) (ABIN8051868)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDP1 Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Produktdetails anti-TDP1 Antikörper (Fluoro594)

Bindungsspezifität: AA 1-499

Verwendungszweck: Anti-TDP1 Antibody Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human TDP1 shares 78.8%,79.6% amino acid (aa) sequence identity with mouse,rat TDP1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TDP1 recombinant protein (Position: M1-R499). Human TDP1 shares 78.8% and 79.6% amino acid (aa) sequence identity with mouse and rat TDP1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Andere Bezeichnung: TDP1

Hintergrund:

Background: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).

Gene Full Name: tyrosyl-DNA phosphodiesterase 1

Gen-ID: 55775

UniProt: Q9NUW8