TPMT Antikörper (AA 1-245) (APC)

Produktnummer ABIN8046144

Der Kaninchen Polyklonal anti-TPMT Antikörper wird verwendet zum Nachweis von TPMT in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für TPMT Antikörper (AA 1-245) (APC) (ABIN8046144)

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TPMT Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-TPMT Antikörper (APC)

Bindungsspezifität: AA 1-245

Verwendungszweck: Anti-TPMT Antibody APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human TPMT recombinant protein (Position: M1-K245).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Andere Bezeichnung: TPMT

Hintergrund:

Background: Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Gene Full Name: thiopurine S-methyltransferase

Gen-ID: 7172

UniProt: P51580