ABL1 Antikörper (pTyr272) (Biotin)

Produktnummer ABIN753615

Dieser Anti-ABL1-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von ABL1 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human.

Kurzübersicht für ABL1 Antikörper (pTyr272) (Biotin) (ABIN753615)

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ABL1 Antikörper (Biotin)

Bindungsspezifität: pTyr272

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform b around the phosphorylation site of Tyr272

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ABL1

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Andere Bezeichnung: c-Abl

Hintergrund:

Synonyms: c Abl phospho Y272, p-c Abl phospho Y272, Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson murine leukemia viral v abl oncogene homolog 1, Abl 1, ABL, Abl protein, Abl1, Bcr/c abl oncogene protein, JTK 7, JTK7, p150 , Proto oncogene tyrosine protein kinase ABL1, Transformation gene oncogene ABL, v abl Abelson murine leukemia viral oncogene homolog 1, v abl.

Background: The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9,22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Gen-ID: 25

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism