PLAT Antikörper (AA 366-562) (Biotin)

Produktnummer ABIN8022879

Der Kaninchen Polyklonal anti-PLAT Antikörper wird verwendet zum Nachweis von PLAT in Proben von Human. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für PLAT Antikörper (AA 366-562) (Biotin) (ABIN8022879)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLAT Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-PLAT Antikörper (Biotin)

Bindungsspezifität: AA 366-562

Verwendungszweck: Anti-TPA Tissue Plasminogen Activator/PLAT Antibody Biotin Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human TPA shares 83%,84% amino acid (aa) sequence identity with mouse,rat TPA,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human TPA recombinant protein (Position: H366-P562). Human TPA shares 83% and 84% amino acid (aa) sequence identity with mouse and rat TPA, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Andere Bezeichnung: PLAT

Hintergrund:

Background: PLAT is also known as tPA. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene Full Name: plasminogen activator, tissue type

Sequence Similarities: Belongs to the peptidase S1 family.

Gen-ID: 5327

UniProt: P00750

Pathways: Autophagie, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interaktom