PELI2 Antikörper (AA 118-420) (FITC)

Produktnummer ABIN8020022

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PELI2 in FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PELI2 Antikörper (AA 118-420) (FITC) (ABIN8020022)

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PELI2 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-PELI2 Antikörper (FITC)

Bindungsspezifität: AA 118-420

Verwendungszweck: Anti-PELI2 Antibody FITC Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human PELI2 shares 97.4% amino acid (aa) sequence identity with mouse?PELI2.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PELI2 recombinant protein (Position: D118-D420). Human PELI2 shares 97.4% amino acid (aa) sequence identity with mouse?PELI2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PELI2

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Andere Bezeichnung: PELI2

Hintergrund:

Background: Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Gene Full Name: pellino E3 ubiquitin protein ligase family member 2

Gen-ID: 57161

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades