PELI2 Antikörper (N-Term)

Produktnummer ABIN5517275

Produktdetails anti-PELI2 Antikörper

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PELI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: STISRFACRI VCDRNEPYTA RIFAAGFDSS KNIFLGEKAA KWKNPDGHMD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against PELI2. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PELI2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PELI2

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Andere Bezeichnung: PELI2 (PELI2 Produkte)

Synonyme: AW047589 antikoerper, BB129927 antikoerper, pellino 2 antikoerper, pellino E3 ubiquitin protein ligase family member 2 antikoerper, Peli2 antikoerper, PELI2 antikoerper

Hintergrund: PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Protein Interaction Partner: SRPK1, FRYL, CREB3L3, THAP7, ERO1L, DEAF1, LAMC3, PICALM, LTBP3, IRAK1, HNRNPK, FN1, UBC, UBQLN4, IRAK4, TRAF6, NR2C2, BCL10, MYD88, IRAK2,

Protein Size: 420

Gen-ID: 57161

NCBI Accession: NP_067078

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades