MUTYH Antikörper (AA 1-559) (HRP)

Produktnummer ABIN8012231

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MUTYH in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für MUTYH Antikörper (AA 1-559) (HRP) (ABIN8012231)

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUTYH Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MUTYH Antikörper (HRP)

Bindungsspezifität: AA 1-559

Verwendungszweck: Anti-MUTYH Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human IFFO1 recombinant protein (Position: M1-R559). Human IFFO1 shares 94.1% amino acid (aa) sequence identity with mouse IFFO1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu MUTYH

Target: MUTYH (MutY Homolog (E. Coli) (MUTYH))

Andere Bezeichnung: MUTYH

Hintergrund:

Background: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: mutY DNA glycosylase

Gen-ID: 4595

UniProt: Q9UIF7

Pathways: DNA Reparatur