LRP5 Antikörper (C-Term) (Fluoro550)

Produktnummer ABIN8006572

Der Fluoro550-konjugierte Kaninchen Polyklonal anti-LRP5 Antikörper (ABIN8006572) detektiert spezifisch LRP5 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für LRP5 Antikörper (C-Term) (Fluoro550) (ABIN8006572)

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP5 Antikörper ist konjugiert mit Fluoro550

Applikation: Flow Cytometry (FACS)

Produktdetails anti-LRP5 Antikörper (Fluoro550)

Bindungsspezifität: C-Term

Verwendungszweck: Anti-LRP5 Antibody Fluoro550 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: identical to the related mouse,rat sequences.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5, identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu LRP5

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Andere Bezeichnung: LRP5

Hintergrund:

Background: Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

Gene Full Name: LDL receptor related protein 5

Sequence Similarities: Belongs to the LDLR family.

Gen-ID: 4041

UniProt: O75197

Pathways: WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation