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LRP5 Antikörper (AA 501-600)

LRP5 Reaktivität: Maus ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN754078
  • Target Alle LRP5 Antikörper anzeigen
    LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
    Bindungsspezifität
    • 17
    • 15
    • 14
    • 8
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600
    Reaktivität
    • 58
    • 46
    • 22
    • 1
    • 1
    Maus
    Wirt
    • 67
    • 5
    • 1
    • 1
    Kaninchen
    Klonalität
    • 70
    • 4
    Polyklonal
    Konjugat
    • 26
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser LRP5 Antikörper ist unkonjugiert
    Applikation
    • 44
    • 37
    • 25
    • 20
    • 12
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody will recognize LRP6 due to high sequence similarity.
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human LRP5
    Isotyp
    IgG
    Top Product
    Discover our top product LRP5 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
    Andere Bezeichnung
    LRP5 (LRP5 Produkte)
    Synonyme
    Xlrp5 antikoerper, bmnd1 antikoerper, evr1 antikoerper, evr4 antikoerper, hbm antikoerper, lr3 antikoerper, lrp5-A antikoerper, lrp7 antikoerper, oppg antikoerper, ops antikoerper, opta1 antikoerper, vbch2 antikoerper, LRP5 antikoerper, LRP6 antikoerper, BMND1 antikoerper, EVR1 antikoerper, EVR4 antikoerper, HBM antikoerper, LR3 antikoerper, LRP7 antikoerper, OPPG antikoerper, OPS antikoerper, OPTA1 antikoerper, VBCH2 antikoerper, mKIAA4142 antikoerper, low-density lipoprotein receptor-related protein 5 antikoerper, LDL receptor related protein 5 antikoerper, LDL receptor related protein 5 L homeolog antikoerper, low density lipoprotein receptor-related protein 5 antikoerper, LDL receptor related protein 5 like antikoerper, LOC100147353 antikoerper, LRP5 antikoerper, lrp5.L antikoerper, lrp5 antikoerper, Lrp5 antikoerper, LRP5L antikoerper
    Hintergrund

    Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

    Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

    Gen-ID
    4041
    UniProt
    O75197
    Pathways
    WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
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