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CUBN Antikörper (AA 51-150)

CUBN Reaktivität: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN750868
  • Target Alle CUBN Antikörper anzeigen
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Bindungsspezifität
    • 14
    • 7
    • 5
    • 2
    • 1
    AA 51-150
    Reaktivität
    • 30
    • 9
    • 7
    Human
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 35
    • 9
    Polyklonal
    Konjugat
    • 12
    • 10
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CUBN Antikörper ist unkonjugiert
    Applikation
    • 22
    • 16
    • 12
    • 12
    • 8
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Cubilin
    Isotyp
    IgG
    Top Product
    Discover our top product CUBN Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Andere Bezeichnung
    Cubilin (CUBN Produkte)
    Synonyme
    GP280 antikoerper, IFCR antikoerper, MGA1 antikoerper, AA408369 antikoerper, AL022750 antikoerper, D2Wsu88e antikoerper, gp280 antikoerper, cubilin antikoerper, cubilin (intrinsic factor-cobalamin receptor) antikoerper, LOC411053 antikoerper, CUBN antikoerper, cubn antikoerper, Cubn antikoerper
    Hintergrund

    Synonyms: IFCR, MGA1, gp280, Cubilin, 460 kDa receptor, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor, CUBN

    Background: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

    Gen-ID
    8029
    UniProt
    O60494
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism
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