IL21 Receptor Antikörper (Middle Region) (Biotin)

Produktnummer ABIN8002321

Der Biotin-konjugierte Kaninchen Polyklonal anti-IL21 Receptor Antikörper (ABIN8002321) detektiert spezifisch IL21 Receptor in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL21 Receptor Antikörper (Middle Region) (Biotin) (ABIN8002321)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL21 Receptor Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-IL21 Receptor Antikörper (Biotin)

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-IL21R Antibody Biotin Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL21R. Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: IL21R

Hintergrund:

Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Gene Full Name: interleukin 21 receptor

Gen-ID: 50615

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg