ITGAL Antikörper (AA 161-349) (Biotin)

Produktnummer ABIN8000451

Der Kaninchen Polyklonal anti-ITGAL Antikörper wird verwendet zum Nachweis von ITGAL in Proben von Human. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für ITGAL Antikörper (AA 161-349) (Biotin) (ABIN8000451)

Target: ITGAL (Integrin alpha-L (ITGAL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGAL Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-ITGAL Antikörper (Biotin)

Bindungsspezifität: AA 161-349

Verwendungszweck: Anti-CD11a/ITGAL Antibody Biotin Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human CD11a shares 73.7% mino acid (aa) sequence identity with mouse CD11a.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CD11a recombinant protein (Position: F161-L349). Human CD11a shares 73.7% mino acid (aa) sequence identity with mouse CD11a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Andere Bezeichnung: ITGAL

Hintergrund:

Background: CD11a, also known as ITGAL or LFA-1, is a human gene which functions in the immune system. It is mapped to 16p11.2. CD11a is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. CD11a encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. It is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Gene Full Name: integrin subunit alpha L

Gen-ID: 3683

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex