Gelsolin Antikörper (C-Term) (HRP)

Produktnummer ABIN7993054

Der Kaninchen Polyklonal anti-Gelsolin Antikörper wird verwendet zum Nachweis von Gelsolin in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für Gelsolin Antikörper (C-Term) (HRP) (ABIN7993054)

Target: Gelsolin (GSN)

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Gelsolin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Gelsolin Antikörper (HRP)

Bindungsspezifität: C-Term

Verwendungszweck: Anti-Gelsolin/GSN Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: identical to the related rat sequence,and different from the related mouse sequence by one amino acid.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Gelsolin, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Gelsolin

Target: Gelsolin (GSN)

Andere Bezeichnung: GSN

Hintergrund:

Background: Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor, it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. Gelsolin may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.

Gene Full Name: gelsolin

Sequence Similarities: Belongs to the villin/gelsolin family.

Gen-ID: 2934

UniProt: P06396

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie