Fibrillarin Antikörper (AA 77-138) (HRP)

Produktnummer ABIN7990285

Der Kaninchen Polyklonal anti-Fibrillarin Antikörper wird verwendet zum Nachweis von Fibrillarin in Proben von Human und Affe. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für Fibrillarin Antikörper (AA 77-138) (HRP) (ABIN7990285)

Target: Fibrillarin (FBL)

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibrillarin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Fibrillarin Antikörper (HRP)

Bindungsspezifität: AA 77-138

Verwendungszweck: Anti-Fibrillarin/FBL Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Fibrillarin/FBL recombinant protein (Position: K77-N138).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Fibrillarin

Target: Fibrillarin (FBL)

Andere Bezeichnung: FBL

Hintergrund:

Background: rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene. This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

Gene Full Name: fibrillarin rRNA 2'-O-methyltransferase

Gen-ID: 2091

UniProt: P22087

Pathways: Ribonucleoside Biosynthetic Process