ERCC5 Antikörper (AA 115-964) (APC)

Produktnummer ABIN7985958

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ERCC5 in FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für ERCC5 Antikörper (AA 115-964) (APC) (ABIN7985958)

Target: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC5 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-ERCC5 Antikörper (APC)

Bindungsspezifität: AA 115-964

Verwendungszweck: Anti-XPG/ERCC5 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human XPG,ERCC5 shares 66.6% amino acid (aa) sequence identity with mouse XPG,ERCC5.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human XPG/ERCC5 recombinant protein (Position: K115-R964). Human XPG/ERCC5 shares 66.6% amino acid (aa) sequence identity with mouse XPG/ERCC5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu ERCC5

Target: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Andere Bezeichnung: ERCC5

Hintergrund:

Background: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Gene Full Name: ERCC excision repair 5, endonuclease

Gen-ID: 2073

UniProt: P28715

Pathways: DNA Reparatur