DDB2 Antikörper (AA 10-424) (APC)

Produktnummer ABIN7983771

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DDB2 in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für DDB2 Antikörper (AA 10-424) (APC) (ABIN7983771)

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDB2 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-DDB2 Antikörper (APC)

Bindungsspezifität: AA 10-424

Verwendungszweck: Anti-DDB2 Antibody APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DDB2 recombinant protein (Position: Q10-R424).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu DDB2

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Andere Bezeichnung: DDB2

Hintergrund:

Background: DNA damage-binding protein 2?is a?protein?that in humans is encoded by the?DDB2?gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: damage specific DNA binding protein 2

Gen-ID: 1643

UniProt: Q92466

Pathways: DNA Reparatur