Integrin Alpha2b Antikörper (AA 351-450)

Produktnummer ABIN748358

Der Kaninchen Polyklonal Anti-Integrin Alpha2b-Antikörper wurde für FACS, WB, ELISA, IHC (fro), IHC (p), IF (p) und IF (cc) validiert. Er ist geeignet, Integrin Alpha2b in Proben von Human und Ratte zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für Integrin Alpha2b Antikörper (AA 351-450) (ABIN748358)

Target: Integrin Alpha2b (CD41)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin Alpha2b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-Integrin Alpha2b Antikörper

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Integrin alpha 2b

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Integrin Alpha2b Antikörper (ABIN748358)

Sugiyama, Gamage, Zyla, Armstrong, Advani, Advani, Wang, Lee: "Influenza Virus Infection Induces Platelet-Endothelial Adhesion Which Contributes to Lung Injury." in: Journal of virology, Vol. 90, Issue 4, pp. 1812-23, (2016) (PubMed).

Araki, Ogawara, Suzuki, Kawai, Watanabe, Ono, Higaki: "Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 200, pp. 106-14, (2015) (PubMed).

Lê, Schneider, Boergeling, Berri, Ducatez, Guerin, Adrian, Errazuriz-Cerda, Frasquilho, Antunes, Lina, Bordet, Jandrot-Perrus, Ludwig, Riteau: "Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis." in: American journal of respiratory and critical care medicine, (2015) (PubMed).

Mei, Yin, Jin, He, Yin: "The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation." in: Endocrinology, Vol. 154, Issue 12, pp. 4640-9, (2013) (PubMed).

Details zu Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Andere Bezeichnung: Integrin alpha 2b/CD41

Hintergrund:

Synonyms: CD41, CD41B, GpIIb, AI172977, alphaIIb, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, Itga2b

Background: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Gen-ID: 16399

UniProt: Q9QUM0

Pathways: Integrin Complex