NSUN2 Antikörper

Produktnummer ABIN7938379

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NSUN2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NSUN2 Antikörper (ABIN7938379)

Target: NSUN2 (NOP2/Sun Domain Family, Member 2 (NSUN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSUN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NSUN2 Antikörper

Verwendungszweck: NSUN2 antibody (pAb)

Aufreinigung: Protein A Chromatography

Immunogen: Peptide within the human NSUN2 (RNA cytosine C(5)-methyltransferase NSUN2) isoform 1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5 - 2.0 μg/mL dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu NSUN2

Target: NSUN2 (NOP2/Sun Domain Family, Member 2 (NSUN2))

Andere Bezeichnung: NSUN2

Hintergrund:

Background_Plain: NSUN2 (NOP2/Sun Domain Family, Member 2), also called TRM4 (TRNA Methyltransferase 4 Homolog), is a member of NSUN family. It's a RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. NSUN2 also methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron containing. tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. It may act downstream of Myc to regulate epidermal cell growth and proliferation.NSUN2 is required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.

Aliases: NOP2/Sun RNA Methyltransferase Family Member 2, Myc-Induced SUN-Domain-Containing Protein, MISU, SAKI, MRT5

Molekulargewicht: 100 kDa

NCBI Accession: NP_060225