Prokineticin Receptor 1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885321

Der Kaninchen Polyklonal anti-Prokineticin Receptor 1 Antikörper wird verwendet zum Nachweis von Prokineticin Receptor 1 in Proben von Maus und Ratte. Er wurde validiert für WB, IHC, IF, FACS und LCI.

Kurzübersicht für Prokineticin Receptor 1 Antikörper (Extracellular, N-Term) (ABIN7885321)

Target: Prokineticin Receptor 1 (PROKR1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prokineticin Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Prokineticin Receptor 1 Antikörper

Bindungsspezifität: AA 10-24, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Prokineticin Receptor 1

Homologie: Mouse - 12,15 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)ENTTNTFTDFFSARD, corresponding to amino acid residues 10-24 of rat PROKR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236609)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Prokineticin Receptor 1

Target: Prokineticin Receptor 1 (PROKR1)

Andere Bezeichnung: PROKR1

Hintergrund:

Synonyms: PROKR1, PKR1, G-protein coupled receptor 73, Gpr73, Gpr73a, G-protein coupled receptor ZAQ

Description: The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin receptor 1 (PKR1) and Prokineticin receptor 2 (PKR2) that belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization. In addition, activation of the mitogen-activated protein kinase (MAPK) pathways has also been described.1PKR1 is broadly distributed throughout peripheral tissues including the intestinal tract, testis, uterus, lung and peripheral blood leukocytes. In addition, the receptor is expressed in the brain, particularly in olfactory regions, as well as in dorsal root ganglion (DRG) neurons.The physiological function of PKR1 is still being elucidated, however, evidence suggest that the receptor has an important role in pain perception through its ability to stimulate the TRPV1 ion channel in DRG neurons.2In addition, a role for PKR1 in the control of the inflammatory response through regulation of macrophage chemotaxis and cytokine production has also been demonstrated.3

Gen-ID: 192648

UniProt: Q8R416

Pathways: Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma