Neurexin 1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885166

Der Kaninchen Polyklonal anti-Neurexin 1 Antikörper (ABIN7885166) detektiert spezifisch Neurexin 1 in WB, IF, IC und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Neurexin 1 Antikörper (Extracellular, N-Term) (ABIN7885166)

Target: Neurexin 1 (NRXN1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurexin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-Neurexin 1 Antikörper

Bindungsspezifität: AA 546-560, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neurexin 1α

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 of rat Nrxn1alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236037)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Neurexin 1

Target: Neurexin 1 (NRXN1)

Andere Bezeichnung: Nrxn1

Hintergrund:

Synonyms: Nrxn1, Neurexin I-alpha

Description: Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins2. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer α-isoform (α-NRXNs) and a downstream promoter to generate a shorter β-isoform (β- NRXNs).The α- and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors3. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns4. The extracellular domain of neurexin 1α (NRXN1α) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1α binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, α-dystroglycan, and GABA(A) receptors.NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia and Autism Spectrum Disorder5.

Gen-ID: 60391

UniProt: Q63372

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development