Neurexin 1 Antikörper (N-Term)

Produktnummer ABIN6263607

Produktdetails anti-Neurexin 1 Antikörper

Target: Neurexin 1 (NRXN1)

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurexin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Neurexin I Antibody detects endogenous levels of total Neurexin I.

Homologie: Bovine

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Neurexin I, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Neurexin 1

Target: Neurexin 1 (NRXN1)

Andere Bezeichnung: NRXN1 (NRXN1 Produkte)

Synonyme: Hs.22998 antikoerper, PTHSL2 antikoerper, SCZD17 antikoerper, CG7050 antikoerper, CT21808 antikoerper, Dmel\\CG7050 antikoerper, Nrx antikoerper, Nrx1 antikoerper, dnrx antikoerper, dnrx-1 antikoerper, nrx antikoerper, Nrxn1b antikoerper, NRXN1 antikoerper, Nrx-1 antikoerper, GB13455 antikoerper, GB18754 antikoerper, 1700062G21Rik antikoerper, 9330127H16Rik antikoerper, A230068P09Rik antikoerper, mKIAA0578 antikoerper, neurexin 1 antikoerper, Neurexin 1 antikoerper, neurexin I antikoerper, neurexin 1b antikoerper, neurexin 1a antikoerper, NRXN1 antikoerper, Nrx-1 antikoerper, Nrxn1 antikoerper, nrxn1 antikoerper, nrxn1b antikoerper, nrxn1a antikoerper

Hintergrund:

Description: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).

Gene: NRXN1

Molekulargewicht: 150kDa

Gen-ID: 9378

UniProt: Q9ULB1

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development