Neurexin 1 Antikörper (AA 480-560)

Produktnummer ABIN7225960

Der Kaninchen Polyklonal anti-Neurexin 1 Antikörper wird verwendet zum Nachweis von Neurexin 1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB und IHC.

Kurzübersicht für Neurexin 1 Antikörper (AA 480-560) (ABIN7225960)

Target: Neurexin 1 (NRXN1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurexin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Neurexin 1 Antikörper

Bindungsspezifität: AA 480-560

Verwendungszweck: Rabbit Anti-Neurexin I Polyclonal Antibody

Spezifität: Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neurexin I at AA range: 480-560

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Neurexin 1

Target: Neurexin 1 (NRXN1)

Andere Bezeichnung: Neurexin I

Hintergrund: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alphaNRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Molekulargewicht: 150kD

Gen-ID: 9378

UniProt: Q9ULB1

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development