EPH Receptor A6 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884939

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch EPH Receptor A6 in WB, IHC, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für EPH Receptor A6 Antikörper (Extracellular, N-Term) (ABIN7884939)

Target: EPH Receptor A6 (Epha6)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-EPH Receptor A6 Antikörper

Bindungsspezifität: AA 482-495, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to EphA6 Receptor

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KEHEQLTYSSTRSK, corresponding to amino acid residues 482-495 of rat EphA6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235290)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu EPH Receptor A6

Target: EPH Receptor A6 (Epha6)

Andere Bezeichnung: Ephrin type-A receptor 6

Hintergrund:

Synonyms: Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2

Description: EphA6 is an erythropoietin-producing hepatocellular (Eph) receptor that belongs to the tyrosine kinase receptor family. The Eph receptor family consists of 9 EphA receptors and 5 EphB receptors, which serve key roles in normal physiology, including cell migration, cell adhesion, cell proliferation and neuronal synaptic plasticity. These activities depend on the binding of their Eph receptor-interacting (ephrin) proteins, of which include 8 members. Compelling data has demonstrated that Eph receptors and ephrins affect tumor growth, invasiveness, angiogenesis and metastasis1. They are also involved in brain development, learning and memory2.EphA6 signaling pathways are inhibitory for developing axons and blocking these pathways enhances regeneration following spinal cord and brain injury, rendering EphA6 an appealing drug target3.Eph receptors contain an extracellular structure consisting of an ephrin binding domain, the juxtamembrane region connects the extracellular portion of the receptor to the intracellular kinase domain. Two Tyrosine residues on the juxtamembrane region mediate autophosphorylation and receptor dimerization mediates the formation of heterocomplexes that are required for signaling4.

Gen-ID: 29202

UniProt: P54758

Pathways: RTK Signalweg