EPH Receptor A5 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7884937

Der Kaninchen Polyklonal anti-EPH Receptor A5 Antikörper wird verwendet zum Nachweis von EPH Receptor A5 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für EPH Receptor A5 Antikörper (Extracellular, N-Term) (ABIN7884937)

Target: EPH Receptor A5 (EPHA5)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-EPH Receptor A5 Antikörper

Bindungsspezifität: AA 357-369, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to EphA5 (Extracellular)

Homologie: Rat,human - 12 out of 13 amino acids identical.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KSKETSITAEGLK, corresponding to amino acid residues 357 - 369 of mouse EPHA5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu EPH Receptor A5

Target: EPH Receptor A5 (EPHA5)

Andere Bezeichnung: EPHA5

Hintergrund:

Synonyms: Ephrin type A receptor 5, Brain specific kinase, EPHA5

Description:

EphA5 (EPH Receptor A5) is a member of the Eph receptor tyrosine kinase family, which is the largest group of receptor tyrosine kinases (RTKs) in the human genome. They are divided into two classes-EphA and EphB-based on sequence similarity and ligand binding preferences. EphA receptors (EphA1-A10) typically bind to glycosylphosphatidylinositol (GPI)-anchored ephrin-A ligands, whereas EphB receptors (EphB1-B6) bind to transmembrane ephrin-B ligands.1

EphA5 is predominantly expressed in the developing central nervous system, especially in the cortex, hippocampus, olfactory bulb, and retina. It is critically involved in axon guidance, particularly in the formation of retinotectal and thalamocortical projections, contributing to the correct mapping of neural circuits. In the adult brain, EphA5 influences dendritic spine maturation and synaptic plasticity, which are fundamental for learning and memory.2,3

Eph receptors, including EphA5, are often dysregulated in cancer. EphA5 displays context-dependent roles in cancer, acting as either a tumor suppressor or, in some cases, a tumor promoter, depending on the cellular environment and tumor type. Its role is influenced by its expression pattern, epigenetic status, and interactions with other signaling pathways.4 In certain cancers such as breast and prostate, EphA5 is downregulated, suggesting a tumor-suppressive function, while in others like lung and gastric cancer, EphA5 expression is elevated and correlates with a more aggressive cancer.5,6

All these makes EphA5 a promising target for therapeutic intervention. Indeed, recently an antibody-drug conjugate (ADC) targeting EphA5, has been developed as a highly selective target for directed anticancer therapy.7

Gen-ID: 13839

UniProt: Q60629

Pathways: RTK Signalweg