Adenosine A3 Receptor Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7884727

Der Kaninchen Polyklonal anti-Adenosine A3 Receptor Antikörper wird verwendet zum Nachweis von Adenosine A3 Receptor in Proben von Human. Er wurde validiert für WB, FACS und LCI.

Kurzübersicht für Adenosine A3 Receptor Antikörper (2nd Extracellular Loop) (ABIN7884727)

Target: Adenosine A3 Receptor (ADORA3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Adenosine A3 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-Adenosine A3 Receptor Antikörper

Bindungsspezifität: 2nd Extracellular Loop, AA 152-166

Verwendungszweck: A rabbit polyclonal antibody to Human Adenosine A3 Receptor (extracellular)

Homologie: Human only

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: Peptide KLTSEYHRNVTFLSC, corresponding to amino acid residues 152 - 166 of human ADORA3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Adenosine A3 Receptor

Target: Adenosine A3 Receptor (ADORA3)

Andere Bezeichnung: ADORA3

Hintergrund:

Synonyms: Adenosine receptor A3, A3AR, AA3R, ADORA3

Description:

Adenosine A3 receptor (also known as ADORA3), is a member of the G protein-coupled receptor (GPCR) family that plays a crucial role in regulating a wide range of physiological processes, especially those related to inflammation, immunity, and cell survival. It is one of four receptors activated by adenosine, a purine nucleoside that functions as a local modulator of cellular activity in response to stress, hypoxia, or tissue damage.1

Encoded by the ADORA3 gene, this receptor is primarily coupled to Gi/o proteins, resulting in the inhibition of adenylate cyclase and a subsequent decrease in cyclic AMP (cAMP) levels. Beyond this classical signaling pathway, ADORA3 activation triggers multiple intracellular cascades, such as MAPK/ERK, PI3K/Akt, and PLCβ/DAG/IP3, which together regulate critical cellular functions including apoptosis, proliferation, cytokine production, and oxidative stress responses.1,2

The ADORA3 receptor is broadly expressed across various tissues, including immune cells, the central nervous system, cardiac tissue, lungs, and liver. In immune cells such as neutrophils, mast cells, and lymphocytes, ADORA3 plays a key anti-inflammatory role by modulating cytokine secretion and reducing the activation of pro-inflammatory pathways. This has made it a target of interest in the treatment of autoimmune and inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, and psoriasis.2,3,4

In oncology, ADORA3 is often overexpressed in various tumors, including breast, colon, and melanoma cancers. Its activation in cancer cells can lead to apoptosis and inhibition of angiogenesis, positioning it as a potential target for anticancer therapies. Interestingly, it may exert opposite effects in different cellular environments, reflecting its complex and context-dependent nature.4,5

In summary, the ADORA3 receptor is a multifaceted regulatory molecule at the crossroads of inflammation, immunity, cardiovascular protection, and cancer biology. Its unique signaling capabilities and tissue-specific roles make it a compelling target for drug development, particularly in diseases characterized by chronic inflammation or uncontrolled cell growth.

Gen-ID: 140

UniProt: P0DMS8

Pathways: Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process