Spectrin beta Chain, Erythrocyte (SPTB) Antikörper

Produktnummer ABIN7882347

Dieser Maus Monoklonal Antikörper detektiert spezifisch Spectrin beta Chain, Erythrocyte in WB, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Spectrin beta Chain, Erythrocyte (SPTB) Antikörper (ABIN7882347)

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: RG-26

Produktdetails

Verwendungszweck: SPTB Antibody / Spectrin beta (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Red cell membranes were used as the immunogen for this Spectrin beta antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SPTB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the SPTB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Andere Bezeichnung: SPTB

Hintergrund: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

UniProt: P11277

Pathways: Regulation of Actin Filament Polymerization