RMI2 Antikörper

Produktnummer ABIN7882182

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RMI2 in WB, FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für RMI2 Antikörper (ABIN7882182)

Target: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RMI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-RMI2 Antikörper

Verwendungszweck: RMI2 Antibody / RecQ-mediated genome instability protein 2

Sequenz: KMTDLSDNPI HESMWELEVE DLHRNIP

Aufreinigung: Antigen affinity purified

Immunogen: Amino acids KMTDLSDNPIHESMWELEVEDLHRNIP from the human protein were used as the immunogen for the RMI2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the RMI2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the RMI2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu RMI2

Target: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Andere Bezeichnung: RMI2

Hintergrund: RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90 % . Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.

UniProt: Q96E14

Pathways: DNA Reparatur