ROR2 Antikörper

Produktnummer ABIN7882144

Der Maus Monoklonal anti-ROR2 Antikörper wird verwendet zum Nachweis von ROR2 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für ROR2 Antikörper (ABIN7882144)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ROR2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: ROR2-1912

Produktdetails anti-ROR2 Antikörper

Verwendungszweck: ROR2 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Cultured human keratinocytes were used as the immunogen for this ROR2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ROR2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the ROR2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Andere Bezeichnung: ROR2

Hintergrund: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

UniProt: Q01974

Pathways: RTK Signalweg, WNT Signalweg