Der Ratte Monoklonal anti-Nidogen Antikörper (Klon ELM1) (ABIN7881809) detektiert spezifisch Nidogen in ELISA.
Dieser Antikörper reagiert spezifisch mit Proben aus Maus.
NID
Reaktivität: Maus
ELISA
Wirt: Ratte
Monoclonal
ELM1
unconjugated
Applikationshinweise
Optimal dilution of the Nidogen antibody should be determined by the researcher.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
1 mg/mL in 1X PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store the Nidogen antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Target
Nidogen (NID)
Andere Bezeichnung
Nidogen
Hintergrund
Entactin/Nidogen is a ubiquitous multi-domain basement membrane protein. Basement membranes are the earliest extracellular matrices produced during embryogenesis. They are synthesized and incorporated into the supramolecular architecture of several components, including laminins, Collagen IV, Nidogen and proteoglycans. Nidogen/Entactin, a sulfated glycoprotein, acts as a link between the extracellular matrix molecules Laminin 1 and Collagen Type IV, and thereby participates in the assembly of basement membranes. Nidogen is synthesized and secreted in primary and established mesenchymal peritubular cells and myoepithelial cells, and it affects adhesion of peritubular cells in an autocrine manner. Nidogen is expressed during embryonic and fetal development exclusively in fully developed basement membranes of the ectoderm and is not expressed in the developing endodermal basement membrane or in membranes disrupted during mesoderm formation. This MAb does not cross-react with other basement membrane components or fibronectin.