Rekombinanter LFNG Antikörper

Produktnummer ABIN7881470

Der Kaninchen Monoklonal anti-LFNG Antikörper (Klon 31L39) (ABIN7881470) detektiert spezifisch LFNG in WB, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter LFNG Antikörper (ABIN7881470)

Target: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LFNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 31L39

Produktdetails anti-LFNG Antikörper

Verwendungszweck: LFNG Antibody / Lunatic Fringe

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Lunatic Fringe was used as the immunogen for the LFNG antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LFNG antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the LFNG antibody at -20oC.

Details zu LFNG

Target: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Andere Bezeichnung: LFNG

Hintergrund: LFNG antibody detects lunatic fringe, a glycosyltransferase that modifies Notch receptors and regulates Notch signaling pathways. LFNG belongs to the fringe family of glycosyltransferases, which add N-acetylglucosamine residues to O-fucose on epidermal growth factor-like repeats of Notch. This modification alters ligand binding specificity and modulates signaling outcomes critical for development and tissue homeostasis.

Research using LFNG antibody has highlighted the protein's role in embryogenesis. LFNG is required for somitogenesis, the process that establishes segmented structures in the developing embryo. Loss of LFNG function leads to defects in somitic patterning and skeletal abnormalities, demonstrating its importance in developmental timing. Beyond embryonic segmentation, LFNG also contributes to hematopoiesis, vascular development, and neural differentiation by fine-tuning Notch signaling activity.

Dysregulation of LFNG has been implicated in cancer and congenital disorders. Aberrant expression of LFNG can lead to uncontrolled Notch signaling, a hallmark of various malignancies including breast cancer and T-cell acute lymphoblastic leukemia. Reduced LFNG activity may also contribute to congenital scoliosis and vertebral malformations. Understanding how LFNG modifies Notch receptors provides insights into therapeutic targeting of developmental and cancer-related pathways.

Antibodies against LFNG are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable researchers to study expression patterns in embryonic and adult tissues, as well as to evaluate changes in Notch pathway regulation. Clone-based antibodies ensure reliable detection of LFNG across experimental conditions.

NSJ Bioreagents provides this LFNG antibody for developmental biology, cancer, and signaling research.

UniProt: Q8NES3

Pathways: Notch Signalweg