LGR5 Antikörper

Produktnummer ABIN7881466

Der Kaninchen Monoklonal anti-LGR5 Antikörper wird verwendet zum Nachweis von LGR5 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für LGR5 Antikörper (ABIN7881466)

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LGR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: CHF-12

Produktdetails anti-LGR5 Antikörper

Verwendungszweck: GPR49 Antibody / LGR5

Aufreinigung: Affinity purified

Immunogen: A synthetic peptide specific to human GPR49 / LGR5 was used as the immunogen for the GPR49 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GPR49 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the GPR49 antibody at -20oC.

Details zu LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Andere Bezeichnung: GPR49

Hintergrund: G-protein coupled receptor 49,' or 'Leucine-rich repeat-containing G-protein coupled receptor 5' is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]

UniProt: O75473

Pathways: WNT Signalweg