Rekombinanter GNAQ Antikörper

Produktnummer ABIN7880947

Der Kaninchen Monoklonal anti-GNAQ Antikörper (Klon 30G74) (ABIN7880947) detektiert spezifisch GNAQ in WB, IHC, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter GNAQ Antikörper (ABIN7880947)

Target: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser GNAQ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 30G74

Produktdetails anti-GNAQ Antikörper

Verwendungszweck: GNAQ Antibody / Guanine nucleotide binding protein Gq subunit alpha

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human GNAQ was used as the immunogen for the GNAQ antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the GNAQ antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the GNAQ antibody at -20oC.

Details zu GNAQ

Target: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Andere Bezeichnung: GNAQ

Hintergrund: GNAQ antibody detects Guanine nucleotide binding protein Gq subunit alpha, encoded by the GNAQ gene. This protein is a member of the heterotrimeric G protein alpha subunit family and couples receptors to downstream signaling cascades. Upon activation by G protein coupled receptors, GNAQ activates phospholipase C beta, leading to the production of inositol triphosphate and diacylglycerol. GNAQ antibody enables detailed study of this central signaling node and its contribution to cellular communication, growth, and differentiation.

Guanine nucleotide binding protein Gq subunit alpha plays a pivotal role in calcium signaling, activating pathways that regulate smooth muscle contraction, secretion, and gene expression. Dysregulation of GNAQ activity has been linked to developmental disorders, vascular anomalies, and cancers. Mutations in GNAQ are frequent in uveal melanoma and Sturge Weber syndrome, where they drive aberrant MAPK signaling and cell proliferation. Research using GNAQ antibody provides a means to detect altered protein levels and examine how mutant forms disrupt signaling dynamics.

Studies have also shown that GNAQ interacts with multiple effector pathways, including protein kinase C and Rho GTPases, extending its impact on cytoskeletal remodeling, migration, and survival. GNAQ antibody has been used to investigate signaling crosstalk in cardiovascular, neurological, and oncological contexts. Its function in coupling receptors to intracellular calcium release makes it indispensable for understanding receptor mediated physiology and pathology.

GNAQ antibody is employed in western blotting, immunohistochemistry, and immunofluorescence. Western blotting measures expression in tissues such as brain, heart, and smooth muscle. Immunohistochemistry visualizes localization in vascular endothelium and tumor samples. Immunofluorescence reveals distribution at the plasma membrane, consistent with its role as a receptor coupled G protein. Functional experiments have used GNAQ antibody to track expression changes following pharmacological inhibition of GPCR pathways.

By providing validated GNAQ antibody reagents, NSJ Bioreagents supports research in receptor signaling, cancer biology, and cardiovascular physiology. Guanine nucleotide binding protein Gq subunit alpha remains a vital component of GPCR signaling pathways, and detection with GNAQ antibody ensures reliable insights into its regulation and disease relevance.

UniProt: P50148

Pathways: JAK-STAT Signalweg, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction