Rekombinanter Cyclin H Antikörper
Kurzübersicht für Rekombinanter Cyclin H Antikörper (ABIN7880529)
Target
Alle Cyclin H (CCNH) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- CCNH Antibody / Cyclin H
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Aufreinigung
- Affinity chromatography
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Immunogen
- A synthetic peptide derived from human Cyclin H/p34 was used as the immunogen for the CCNH antibody.
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Isotyp
- IgG
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Applikationshinweise
- Optimal dilution of the CCNH antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store the CCNH antibody at -20oC.
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- Cyclin H (CCNH)
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Andere Bezeichnung
- CCNH
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Hintergrund
- Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProt]
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UniProt
- P51946
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Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, M Phase
Target
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