PAK2 Antikörper (pSer20)

Produktnummer ABIN744518

Produktdetails anti-PAK2 Antikörper

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Bindungsspezifität: pSer20

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PAK2 around the phosphorylation site of Ser20

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PAK2

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Andere Bezeichnung: PAK2 (PAK2 Produkte)

Synonyme: PAK65 antikoerper, PAKgamma antikoerper, gamma-PAK antikoerper, 5330420P17Rik antikoerper, A130002K10Rik antikoerper, AI836325 antikoerper, D16Ertd269e antikoerper, PAK-2 antikoerper, mKIAA4182 antikoerper, pak2 antikoerper, cb422 antikoerper, kinase antikoerper, zgc:91798 antikoerper, wu:fb71h01 antikoerper, si:dz198m22.1 antikoerper, pak65 antikoerper, pakgamma antikoerper, PAKI antikoerper, Pak3 antikoerper, CH73-159L23.1 antikoerper, wu:fc52b03 antikoerper, zgc:113857 antikoerper, p21 (RAC1) activated kinase 2 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2a antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2b antikoerper, PAK2 antikoerper, Pak2 antikoerper, pak2a antikoerper, pak2.S antikoerper, pak2b antikoerper

Hintergrund:

Synonyms: PAK2 phospho S20, PAK2 phospho Ser20, p-PAK2 S20, p-PAK2 Ser20, CB422, EC 2.7.11.1, Gamma PAK, hPAK65, Kinase, p21 CDKN1A-activated kinase 2a, p21 activated kinase 2, p21 protein Cdc42/Rac-activated kinase 2, p21 protein Cdc42 Rac activated kinase 2, p21-activated kinase, 65-KD antibody p21-activated protein kinase I, p21CDKN1A activated kinase 2, p58, p65PAK, PAK 2, PAK65, PAKgamma, S6 H4 kinase, Serine threonine protein kinase PAK 2.

Background: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.

Gen-ID: 5062

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Lipid Metabolism by PPARalpha