IL21 Receptor Antikörper (Middle Region)

Produktnummer ABIN7879525

Der Kaninchen Polyklonal anti-IL21 Receptor Antikörper (ABIN7879525) detektiert spezifisch IL21 Receptor in WB, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL21 Receptor Antikörper (Middle Region) (ABIN7879525)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL21 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-IL21 Receptor Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: IL21R Antibody / Interleukin-21 receptor

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL21R was used as the immunogen for the IL21R antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IL21R antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IL21R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: IL21R

Hintergrund: IL21R antibody detects Interleukin-21 receptor, a type I cytokine receptor that mediates signaling of interleukin-21, a key regulator of immune cell proliferation and differentiation. The UniProt recommended name is Interleukin-21 receptor (IL21R). This transmembrane receptor pairs with the common gamma chain (IL2RG) to form a heterodimeric signaling complex that activates the JAK/STAT pathway in lymphoid cells.

Functionally, IL21R antibody identifies a 538-amino-acid receptor composed of an extracellular cytokine-binding domain, a single transmembrane segment, and a cytoplasmic tail containing Box1 and Box2 motifs that recruit Janus kinases (JAK1 and JAK3). IL21R engagement by IL21 triggers STAT1 and STAT3 phosphorylation, promoting differentiation of B cells, T follicular helper cells, and cytotoxic CD8+ T cells.

The IL21R gene is located on chromosome 16p11.2 and is expressed primarily in lymphocytes, including B cells, natural killer cells, and T cells. Through IL21 signaling, IL21R regulates immunoglobulin production, cytotoxicity, and inflammatory cytokine release. It plays a key role in maintaining immune homeostasis and supporting antibody-mediated immunity.

Pathologically, mutations or altered expression of IL21R are associated with primary immunodeficiency, autoimmune diseases, and lymphoproliferative disorders. Loss of IL21R function impairs B and T cell responses, while overactivation contributes to chronic inflammation. Research using IL21R antibody supports studies in immunology, cytokine signaling, and immune regulation.

IL21R antibody is validated for use in western blotting, flow cytometry, and immunohistochemistry to detect receptor expression and signaling status. NSJ Bioreagents provides high-quality IL21R antibody reagents optimized for cytokine signaling, immunotherapy, and immune cell differentiation research.

Structurally, Interleukin-21 receptor shares homology with other gamma-chain cytokine receptors, featuring fibronectin type III-like domains for ligand binding. This antibody enables detailed analysis of IL21R's function in immune communication and adaptive responses.

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg