UBE2C Antikörper (full length)

Produktnummer ABIN7879293

Der Maus Monoklonal anti-UBE2C Antikörper wird verwendet zum Nachweis von UBE2C in Proben von Human. Er wurde validiert für ELISA und IHC (p).

Kurzübersicht für UBE2C Antikörper (full length) (ABIN7879293)

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser UBE2C Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: CPTC-UBE2C-1

Produktdetails anti-UBE2C Antikörper

Bindungsspezifität: full length

Verwendungszweck: UBE2C Antibody / UBCH10 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the UBE2C antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the UBE2C antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the UBE2C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu UBE2C

Target: UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))

Andere Bezeichnung: UBE2C

Hintergrund: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ubconjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

UniProt: O00762

Pathways: Ubiquitin Proteasome Pathway