Spastin Antikörper (full length)

Produktnummer ABIN7879070

Dieser Maus Monoklonal Antikörper detektiert spezifisch Spastin in WB und IF. Es zeigt Reaktivität gegenüber Proben von Maus, Ratte und Human.

Kurzübersicht für Spastin Antikörper (full length) (ABIN7879070)

Target: Spastin (SPAST)

Reaktivität: Maus, Ratte, Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Spastin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: Sp 6C6

Produktdetails anti-Spastin Antikörper

Bindungsspezifität: full length

Verwendungszweck: Spastin Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant full length human Spastin protein was used as the immunogen for the Spastin antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Spastin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Spastin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Spastin

Target: Spastin (SPAST)

Andere Bezeichnung: Spastin

Hintergrund: The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.

Pathways: Microtubule Dynamics, M Phase, Regulation of Cell Size