MTF1 Antikörper (full length)

Produktnummer ABIN7878611

Dieser Maus Monoklonal Antikörper detektiert spezifisch MTF1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MTF1 Antikörper (full length) (ABIN7878611)

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: MTF1-2649

Produktdetails anti-MTF1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: MTF1 Antibody / Metal regulatory transcription factor 1 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for the MTF1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MTF1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the MTF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Andere Bezeichnung: MTF1

Hintergrund: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

UniProt: Q14872