MTF1 Antikörper

Produktnummer ABIN6937919

Produktdetails anti-MTF1 Antikörper

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human MTF1 protein

Klon: MTF1-2649

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human kidney.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Andere Bezeichnung: MTF1 (MTF1 Produkte)

Synonyme: MTF-1 antikoerper, MTF1 antikoerper, mtf1 antikoerper, MGC86485 antikoerper, Thyls antikoerper, ZRF antikoerper, metal regulatory transcription factor 1 antikoerper, metal-regulatory transcription factor 1 antikoerper, metal-regulatory transcription factor 1 L homeolog antikoerper, metal response element binding transcription factor 1 antikoerper, MTF1 antikoerper, mtf1 antikoerper, mtf1.L antikoerper, Mtf1 antikoerper

Hintergrund: Metal regulatory transcription factor 1, Metal response element binding transcription factor 1, Metal responsive transcription factor 1, MRE-binding transcription factor 1, MTF1, Transcription factor MTF1, Zinc regulatory factor (ZRF),MTF1
Cellular localisation: Nucleus.

Molekulargewicht: 70kDa

Gen-ID: 4520, 471991

UniProt: Q14872