MTF1 Antikörper

Produktnummer ABIN6940090

Produktdetails anti-MTF1 Antikörper

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length human MTF1 protein

Klon: MTF1-2649

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human kidney.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Andere Bezeichnung: MTF1 (MTF1 Produkte)

Synonyme: MTF-1 antikoerper, MTF1 antikoerper, mtf1 antikoerper, MGC86485 antikoerper, Thyls antikoerper, ZRF antikoerper, metal regulatory transcription factor 1 antikoerper, metal-regulatory transcription factor 1 antikoerper, metal-regulatory transcription factor 1 L homeolog antikoerper, metal response element binding transcription factor 1 antikoerper, MTF1 antikoerper, mtf1 antikoerper, mtf1.L antikoerper, Mtf1 antikoerper

Hintergrund: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

Molekulargewicht: 70kDa

Gen-ID: 4520

UniProt: Q14872