Gelsolin Antikörper (full length)

Produktnummer ABIN7878275

Dieser Maus Monoklonal Antikörper detektiert spezifisch Gelsolin in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Gelsolin Antikörper (full length) (ABIN7878275)

Target: Gelsolin (GSN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Gelsolin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: CPTC-Gelsolin-1

Produktdetails anti-Gelsolin Antikörper

Bindungsspezifität: full length

Verwendungszweck: Gelsolin Antibody / GSN

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for this Gelsolin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Gelsolin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Gelsolin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Gelsolin

Target: Gelsolin (GSN)

Andere Bezeichnung: Gelsolin

Hintergrund: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

UniProt: P06396

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie